Differences
between Humoral Immunity and Cell mediated Immunity.
S.N. Characteristics Humoral Immunity Cell-mediated Immunity 1. Definition The immunity mediated by
macromolecules found in the extracellular body fluids is called humoral
immunity. (“humor” a medieval term for body fluid) The immunity that identifies
and destroys infected cells in the body is called cell-mediated immunity. 2. Mediator The main cell involved in
humoral immunity are B-cells. The main cell involved in
cell-mediated immunity are T-cells. 3. Components B cells, T cells, and macrophages. Helper T cells, cytotoxic
T-cells, natural killer cells, and macrophages. 4. Pathogen The humoral immunity protects
against extracellular pathogens and also their toxin. The cell-mediated immunity
protects against intracellular pathogens. 5. Pathogen recognition Recognize antigens or
pathogens that are circulating in the lymph or blood. It responds to any cell that
displays aberrant MHC markers, including cells invaded by pathogens, tumor
cells, or transplanted cells. 6. Antigen detectors Phagocytes and antibodies
themselves are used to detect antigens. Receptors and MHC molecules
on the cell surfaces are used to detect antigens. 7. Antigen Binding B-cells produce antibodies
and the antibodies bind to antigens. T-cell receptors on cells
bind to T-cells which in turn bind to antigens. 8. Antigen Processing Do not require the processing
of antigens. Antigens must be processed
and presented for T-lymphocyte mediated response. 9. Receptor Involved It involves B-cell receptors
(BCRs). It involves T-cell receptors
(TCRs). 10. Accessory surface receptors/molecules Igα, Igβ, Fc receptors, CD40,
CD21 CD3 molecular complex Dimer of ∑ chain, CD4, CD8,
CD2, CD28, integrins 11. Type of T-cell involved Only the T helper cell (CD4+)
is involved. Both CD4+ and CD8+ T cells
are involved. 12. Antibodies formation Antibodies are formed in a
humoral response. Antibodies are not formed in
a cell-mediated immune response. 13. Onset The onset is rapid. The onset is delayed. 14. Result The end result of the
activation is the differentiation of plasma B-cells, secreting antibodies. The end result of the
activation is the secretion of cytokines. 15. Protection against Extracellular bacterial or
viral pathogens. It protects against fungus,
viruses, and intracellular bacterial pathogens. 16. Immunological surveillance It does not provide
immunological surveillance. It provides immunological
surveillance. 17. Hypersensitivity reactions Hypersensitivity type I, II,
and III is mediated by humoral immunity. Hypersensitivity type IV is
mediated by cell-mediated immunity. 18. Role in Organ transplantation
and Grafting It may be involved in early
graft rejection due to preformed antibodies. It participates in rejections
of organ transplants. 19. Immunity against cancer It does not provide immunity
against cancer. As it destroys the tumor and
cancerous cells, it provides protection against cancer. 20. Assessment method From plasma level of
antibodies Skin test for the development
of delayed-type of hypersensitivity
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