Differences between Innate Immunity and Adaptive Immunity

Differences between Innate Immunity and Adaptive Immunity

 

Differences between Innate Immunity and Adaptive Immunity

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S.N.

Characteristics

Innate Immunity

Adaptive Immunity

1.

Synonyms

Nonspecific, natural immunity

Specific, acquired immunity

2.

Definition

The defense mechanisms that are non-antigen specific and immediately come into play on the antigen’s appearance in the body. 

The defense mechanism that is not always present but involve antigen-specific immune response.

3.

Order of defense

It is the first line of defense of immune system.

It is the action against pathogens that are able to evade or overcome innate immune defenses. 

4.

State at birth

Presence since birth.

Acquired during lifetime.

5.

Presence

Always present in the body itself.

Developed only upon exposure to antigens.

6.

Inducible

No

Yes

7.

Cells involved

Physical epithelial barriers, Phagocytic leukocyte, Dendritic cells, Natural killer (NK) cell, Mast cells etc.

Killer CD8+ T-cells, Helper CD4+ T-cells, B-cells, Antigen presenting cells etc.

8.

Molecules involved

Cytokines, Complements ,Interferon, Acute phase proteins.

Antibodies

 Cytokines

9.

Fights against

Fights any foreign invader and thus is non-specific.

Ability to fight a specific infection.

10.

Receptors involved

Uses receptors that recognize conserved pathogen-associated molecular patterns (PAMPs) such as LPS, flagellin, nucleic acids.

Uses recombined B- and T-cell receptors that recognize specific antigens on pathogens

 

11.

Effector function

Constitutive effective functions encoded in the germline (inflammation, phagocytosis)

Inducible effector functions (proliferation, activation, maturation, differentiation)

12.

Response time

Occurs rapidly from minutes to hours.

Occurs over days to weeks.

13.

Immunological memory

Does not confer memory

Confer  immunological memory

14.

Directed against

Innate immunity is directed towards types of molecules.

It is directed towards specific epitopes.

15.

Subsequent exposure

The immune response does not alter on repeated exposure.

Immune response improves with each successive exposure.

16.

Types of immune response

Types of adaptive immune responses: Inflammation, Complement mediated killing, Phagocytosis etc.

Two types of adaptive immune responses: humoral immunity, mediated by antibodies produced by B lymphocytes, and cell-mediated immunity, mediated by T lymphocytes.

17.

Changeability

May vary between individuals but does not change over course of an individual lifetime

Immunity is generated by recombination of V, D, and J regions and further hypervariation thus may change.

18.

Diversity

Limited

Diverse

19.

Potency

Limited and Lower potency

Higher potency

20.

Inheritance

Inherited from parents 

Not inherited from parents 

21.

Time span

Once activated against a specific type of antigen, the immunity remains throughout the life.

The span of developed immunity can be lifelong or short.

22.

Complexity

Innate immune response is less complex.

More complex than the innate immune response.

23.

Anatomic and physiological barriers

Skin, Mucous membranes, Temp, pH, chemicals, etc.

Lymph nodes, spleen, mucosal associated lymphoid tissue.

24.

Allergy or Hypersensitivity reaction

None

Immediate and Delay hypersensitivity

25.

Complement system activation

 

Alternative and lectin pathways

Classical pathway

26.

Found in

Found in nearly all forms of life.

Found only in jawed vertebrates.

27.

Factors causing immune evasion

Caused by pathogenic virulence factor.

Often involves disabling the conserved pattern recognition used by innate system

Caused by mutation of the recognized antigen.

28.

Functions

a) Recruiting immune cells to sites of infection

b) Activation of the complement cascade to identify antigens

c) Identification and removal of foreign substances present in organs, tissues, blood and lymph.

d) Activation of the adaptive immune system through antigen presentation.

e) Acting as a physical and chemical barrier to infectious agents.

a) Recognition of specific “non-self” antigens during the process of antigen presentation.

b) Generation of responses that are tailored to maximally eliminate specific pathogens or pathogen-infected cells.

c) Development of immunological memory, through memory B cells and memory T cells.

29.

Examples

White blood cells fighting bacteria, causing redness and swelling during a cut.

Administration of Chickenpox vaccination such that an individual do not develop chickenpox as adaptive immunity forms immunological memory.


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