Important Points Pathology

 Important Points  Pathology 

 1. Punched out ulcers’ in abomasum- pathognomonic lesion of theileriosis

2. Negri bodies in cattle with rabies seen in cerebellum

3. Father of pathological anatomy Antonio Benevieni

4. Father of cellular pathology Rudolph Virchow

5. Lysosome first demonstrated by Novikoff

6. Most reactive free radical in inducing cell damage Hydroxyl radical

7. Removal of damaged organelle during cell injury is called as Autophagy

8. Component of cytoskeleton useful in tumor diagnosis Intermediate filaments

9. Eosinophilic, intracytoplasmic inclusion in liver in alcoholic liver disease is Mallory body

10. Condition in which impairment of phagocytic property of WBC occurs in Chediak Higashi syndrome

11. Best fixative for glycogen Non-aqueous fixatives(methyl alcohol)

12. Stains for glycogen (any two) Best carmine & PAS

13. Macrophage laden with lipids in atherosclerosis called as Foam cell

14. Russel bodies seen in Plasma cells

15. Partial or complete loss of melanocytes in the epidermis Vitiligo

16. Pigments causing ‘Brown Atrophy’ is Lipofuscin

17. Aggregates of ferritin micelles is called Hemosiderin

18. Heart failure cells are Alveolar macrophage laden with Hemosiderin

19. Unconjugated hyperbilirubinemia is indicative of Prehepatic jaundice

20. Direct Van den berg reaction is indicative of Obstructive jaundice

21. Color of faeces in obstructive jaundice Grey / Clay color

22. Hyperkeratosis in cattle common in which poisoning Chlorinated naphthalene poisoning

23. Type of necrosis involved in hypoxic cell death in the CNS Liquefactive necrosis

24. Necrosis in which architectural details persist but cellular details are lost Coagulative necrosis.

25. Enzymes important in apoptosis Caspases

26. Conditions in which PM clotting of blood doesn’t occur Anthrax and Sweet clover poisoning

27. Pathological calcification without derangement in blood calcium levels Dystrophic calcification

28. Special stain for demonstrating Calcium in tissues Van Kossa’s Silver nitrate

29. ‘Tophi’ is related to which disease Articular gout

30. Condition characterized by green refringence of Congo red stained sections under polarizing microscope Amyloidosis

31. Name the anaphylatoxins C3a and C5a

32. Chemical mediators from arachidonic acid metabolism via cyclooxygenase pathway Thromboxane A2 and Prostaglandins

33. ‘Triple response’ in tissue inflammation was formulated by Sir Thomas Lewis

34. Colloidal carbon technique is used in identifying Leaking vessels in inflammation

35. Name some SRS-A(slow reacting substances of anaphylaxis) Leukotrienes like LTC4, LTD4, LTE4

36. Cationic proteins produced by eosinophils toxic to parasites Major Basic Proteins

37. Suppurative inflammation of hair follicles caused by Staph aureus Boils

38. Diffuse spreading suppurative inflammation of connective tissues Cellulitis

39. Modified macrophages in case of granuloma are called Epitheloid cells

40. Granulation tissue is a hallmark of Healing

41. Adhesive glycoproteins of Extra-cellular matrix. Fibronectin and Laminins

42. Condition in which cardiac sclerosis/ cardiac cirrhosis occurs. Chronic general passive hyperemia

43. Alteration from a less specialized cell type to more specialized ones Metaplasia

44. A malignant tumor which doesn’t metastasize Basal Cell Carcinoma

45. Oncogenes discovered by Michael Bishop and Harold Varmus

46. ‘Sticker tumor’ discovered by Novinsky is better known as Canine Transmissible Venereal Tumor.

47. Reed Sternberg Cells are typical of Hodgkin’s disease

48. Horn cancer is most commonly seen in  Bullock

49. Black tongue/ canine pellagra is caused by Niacin deficiency

50. Rodent ulcer is better known as Basal cell carcinoma